Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEUOBTJ)

• DME Name: Alpha-galactosidase (melA)
• Synonyms: Alpha-D-galactoside galactohydrolase; 1,6-alpha-D-galactoside galactohydrolase; Galactosidase alpha; Ag-I; Ag-II; Aga-F78; Aga-Y; AgaA; agaAJB13; AgaB; AgaI; BGNBKFLM_00010; agaSK
• Gene Name: agaSK
• UniProt ID: A0A564RX90_STRTR
• INTEDE ID: DME1719
• EC Number:
  EC: 3.2.1.22
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.22
• Lineage:
  Species: Streptococcus thermophilus
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Streptococcaceae
  Genus: Streptococcus
  Species: Streptococcus thermophilus
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MSITINKNYYYINSKELSLIIEEREGDLLLRHLGRKITNYHGSNAVNERDHAFSGQLNPD
  IRTYSYDTQRQVLGLHGLGDFRQPSLKIQHGVSDVTRFEFSKAEVVKGISLESKLPYPHS
  LENAETLIFTLVDKVADLELKLYYTVVEDNNTIVTYSEVINNSNQAVVIHRALSAMADVP
  ARDYDVVTLQGAYAREKTVRRQRVEQGIFKVGSNRGASGHAQTPALILCDHEASEGAGEA
  LAFQLMYSGNFQTFVQKSQINEVRVAIGIEDENFTWELASNESFETPVALITYSHQGLTG
  VSQESQAFVTDYIIPKQFAHEERPILLNNWEATYFDFEKEKLLELAEDAKQVGAELFVLD
  DGWFGNRFDDNRALGDWFVNEEKLGGPLQDLIEKVHAKGLKFGLWFEPEMISVDSDLYRK
  HPDWAIQVPNYGHTYSRNQLVLNLANPDVVTYLKDVLDKILTDNAIDYVKWDYNRNITNI
  GNGANYLESQMLSHQYMLGLYDLVEFLTSKHENILFESCSGGGGRNDLGMMRYFPQVWAS
  DNTDAIARLTIQYGSSYLYPTISMGAHVSAVPNHQLERTTPLETRGDVAMMGNLGYELDL
  TSLTQEEKESIAAQIAHYKDIRPVVQFGQQYRLINPEAGSNEAAVQFNYENKVLATYVRI
  LSTIETVETTLKLKNLDQDANYMLQGTGQVYSGAELMYAGITVVLPQGDFLSKQFYFVKV
  D
• Function: This enzyme hydrolyzes alpha-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[1]
Raffinose	DMVHDOS	N. A.	N. A.	Investigative	[1]

References

• [1] Use of an alpha-galactosidase gene as a food-grade selection marker for Streptococcus thermophilus. J Dairy Sci. 2005 Jul;88(7):2341-7.