Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEVJIHS)

• DME Name: Proline dehydrogenase 1 (PRODH)
• Synonyms: Proline oxidase; Proline oxidase 2; Mitochondrial proline dehydrogenase 1; p53-induced gene 6 protein; PIG6; POX2; PRODH; PRODH2
• Gene Name: PRODH
• UniProt ID: PROD_HUMAN
• INTEDE ID: DME0207
• Gene ID: 5625
• EC Number:
  EC: 1.5.5.2
  Oxidoreductase
  CH-NH donor oxidoreductase
  Quinone acceptor oxidoreductase
  EC: 1.5.5.2
• Lineage:
  Species: Homo sapiens
  Kingdom: Metazoa
  Phylum: Chordata
  Class: Mammalia
  Order: Primates
  Family: Hominidae
  Genus: Homo
  Species: Homo sapiens
• Sequence:
  MALRRALPALRPCIPRFVQLSTAPASREQPAAGPAAVPGGGSATAVRPPVPAVDFGNAQE
  AYRSRRTWELARSLLVLRLCAWPALLARHEQLLYVSRKLLGQRLFNKLMKMTFYGHFVAG
  EDQESIQPLLRHYRAFGVSAILDYGVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQ
  YQAHRAFGDRRNGVISARTYFYANEAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGR
  PQFLLQFSEVLAKWRCFFHQMAVEQGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDW
  FTAETLGVSGTMDLLDWSSLIDSRTKLSKHLVVPNAQTGQLEPLLSRFTEEEELQMTRML
  QRMDVLAKKATEMGVRLMVDAEQTYFQPAISRLTLEMQRKFNVEKPLIFNTYQCYLKDAY
  DNVTLDVELARREGWCFGAKLVRGAYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDY
  VLEELKHNAKAKVMVASHNEDTVRFALRRMEELGLHPADHQVYFGQLLGMCDQISFPLGQ
  AGYPVYKYVPYGPVMEVLPYLSRRALENSSLMKGTHRERQLLWLELLRRLRTGNLFHRPA
• Function: This enzyme converts proline to delta-1-pyrroline-5-carboxylate.
• KEGG Pathway:
  Arginine and proline metabolism (hsa00330)
  Metabolic pathways (hsa01100)
• Reactome Pathway: Proline catabolism (R-HSA-70688)

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Proline	DM82TMA	N. A.	N. A.	Investigative	[1]

References

• [1] Proline metabolism and microenvironmental stress. Annu Rev Nutr. 2010 Aug 21;30:441-63.