Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEVNY51)

DME Name	Mercaptosuccinate dioxygenase (efe)
Synonyms	Ethylene-forming enzyme; Succinate-forming enzyme; Cysteine dioxygenase homologue; EFE
Gene Name	efe
UniProt ID	EFE_PSESH
INTEDE ID	DME1566
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 1.14.20.7 Oxidoreductase Oxygen paired donor oxidoreductase 2-oxoglutarate donor oxidoreductase EC: 1.14.20.7
Lineage	Species: Variovorax paradoxus Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Comamonadaceae Genus: Variovorax Species: Variovorax paradoxus Subspecies: Variovorax paradoxus B4
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MTNLQTFELPTEVTGCAADISLGRALIQAWQKDGIFQIKTDSEQDRKTQEAMAASKQFCK EPLTFKSSCVSDLTYSGYVASGEEVTAGKPDFPEIFTVCKDLSVGDQRVKAGWPCHGPVP WPNNTYQKSMKTFMEELGLAGERLLKLTALGFELPINTFTDLTRDGWHHMRVLRFPPQTS TLSRGIGAHTDYGLLVIAAQDDVGGLYIRPPVEGEKRNRNWLPGESSAGMFEHDEPWTFV TPTPGVWTVFPGDILQFMTGGQLLSTPHKVKLNTRERFACAYFHEPNFEASAYPLFEPSA NERIHYGEHFTNMFMRCYPDRITTQRINKENRLAHLEDLKKYSDTRATGS
Function	This enzyme catalyzes the conversion of mercaptosuccinate to sulfinosuccinate by the introduction of two molecules of oxygen.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptosuccinate	DM68FZK	N. A.	N. A.	Investigative	[1]
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References

1	Mercaptosuccinate dioxygenase, a cysteine dioxygenase homologue, from Variovorax paradoxus strain B4 is the key enzyme of mercaptosuccinate degradation. J Biol Chem. 2014 Oct 31;289(44):30800-9.