Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEVOTU4)

• DME Name: Aquaporin adipose (AQP7)
• Synonyms: Aquaglyceroporin-7; Aquaporin-7; Aquaporin-7-like; AQP-7; AQP7; AQP7L; AQP9; AQPap
• Gene Name: AQP7
• UniProt ID: AQP7_HUMAN
• INTEDE ID: DME0407
• Gene ID: 364
• EC Number:
  EC: 3.1.1.-
  Hydrolases
  Ester bond hydrolase
  Carboxylic ester hydrolase
  EC: 3.1.1.-
• Lineage:
  Species: Homo sapiens
  Kingdom: Metazoa
  Phylum: Chordata
  Class: Mammalia
  Order: Primates
  Family: Hominidae
  Genus: Homo
  Species: Homo sapiens
• Sequence:
  MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVL
  NKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQF
  LGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTG
  MLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIA
  GWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITV
  LPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF
• Function: This enzyme functions as important facilitator of glycerol transport across the cell membrane and modulators in controlling the metabolism of glycerol, contributing to the pathophysiology of obesity and diabetes.
• KEGG Pathway:
  PPAR signaling pathway (hsa03320)
  Regulation of lipolysis in adipocytes (hsa04923)
• Reactome Pathway:
  Transport of glycerol from adipocytes to the liver by Aquaporins (R-HSA-432030)
  Passive transport by Aquaporins (R-HSA-432047)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycerol phenylbutyrate	DMDGRQO	Hepatic encephalopathy	DB99.5	Approved	[1]

The Drug Therapeutic Target (DTT) Role of This DME

• DME DTT Name: Aquaporin-7 (AQP7) DTT Info
• DME DTT Type: Literature-reported

References

• [1] Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. Int J Androl. 2010 Aug 1;33(4):629-41.