Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEVSIE6)

• DME Name: Glyceraldehyde-3-phosphate dehydrogenase (gap)
• Synonyms: Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase; DM298_07395; DWV49_09860; FCF10_01070; GAPDH; LAC30SC_03490
• Gene Name: gap
• UniProt ID: A0A3A9YGB0_LACAI
• INTEDE ID: DME1052
• Gene ID: 31801837
• EC Number:
  EC: 1.2.1.-
  Oxidoreductase
  Aldehyde/oxo donor oxidoreductase
  NAD/NADP acceptor oxidoreductase
  EC: 1.2.1.-
• Lineage:
  Species: Lactobacillus acidophilus
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Lactobacillaceae
  Genus: Lactobacillus
  Species: Lactobacillus acidophilus
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MTVKIGINGFGRIGRLAFRRIMDLGEKTKDIEVVAINDLTTPAMLAYLLKYDTTHGTFNH
  EVSSTDDSIVVDGKKYRVYAEPQAQNIPWVKNDGVDFVLECTGFYTSKAKSQAHLDAGAK
  RVLISAPAGNDLKTIVYSVNENTLTADDKIVSAASCTTNSLAPMANALDKEFGIEVATMT
  TIHAYTGTQMTLDGPSRSGKEQDARAAAENIIPHTTGSAKAIGLVLPNLNGKMNGHAQRV
  PVPDGSETELVSILKKKVTADEVNEAMKKYESPSFAYNGDHIVSSDVINMTAGSIFDPTQ
  TMVTTAGDKQLVKTVAWYDNEYSFTCQMVRTLLHFATL
• Function: This enzyme takes part in glucose metabolic process.
• KEGG Pathway:
  Biosynthesis of amino acids (lai01230)
  Biosynthesis of secondary metabolites (lai01110)
  Carbon metabolism (lai01200)
  Glycolysis / Gluconeogenesis (lai00010)
  Metabolic pathways (lai01100)
  Microbial metabolism in diverse environments (lai01120)

Molecular Interaction Atlas (MIA) of This DME

2 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AS-12141	DMIV1WR	N. A.	N. A.	Phase 3	[1]
CERC-801	DM3SZ7P	N. A.	N. A.	Phase 2	[1]

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-mannose	DMT6X03	Discovery agent	N.A.	Investigative	[1]
NA-alpha-D-glucosamine	DMRKIYB	N. A.	N. A.	Investigative	[1]

References

• [1] Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46.