Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEVYB4R)

DME Name	Linoleic acid reductase (cla-r)
Synonyms	Conjugated linoleic acid reductase; Alpha-linoleic acid reductase; Reductase alpha-linoleic acid; cla-r
Gene Name	cla-r
UniProt ID	Q19KJ0_BUTFI
INTEDE ID	DME1861
EC Number	EC: 1.14.14.73 Oxidoreductase Oxygen paired donor oxidoreductase Flavin/flavoprotein donor oxidoreductase EC: 1.14.14.73
Lineage	Species: Butyrivibrio fibrisolvens Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Butyrivibrio Species: Butyrivibrio fibrisolvens
Tissue Distribution	Primarily distributed in human stomach.
Sequence	MADISPKPVKITETVLRDAHQSLIATRMPTSIMLPIIDKMDQVGYNAVECWGGATFDACL RFLKEDPWDRLRQLRDGFKNTKLQMLFRGQNILGYSQYPDDVVEYFVQKSIANGIDIIRI FDCLNDIRNLQTAVNATNKEKGHAQVALSYTLGEAYTLDYWKDIAKRIEDMGASSICIKD MAGLLVPAKASELVSALKESTSLPIELHTHYTSGVASMTYLKAVEAGCDIIDCAMSPFAL GTSQPATEVMAAAFEGTPYDTGFDQELLSEIADYFRPYREECIESGLMSTKVLGVNINTL RYQVPGGMLSNLISQLKEQGKEDKLREVLEEVPRVRKDLGEPPLVTPSSQIVGTQAVFNV LMGERYKVVTEQTKDILLGKYGQTVKPFNPEVVEKALGAELRYAITCRPADLLEPGLKKF EEECARWKQQDEDVLSYALFPKVATEFFEYREAQQTKVDPAKADKENKAYPV
Function	This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bovinic acid	DMRELJ0	N. A.	N. A.	Investigative	[1]
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References

1	Effect of linoleic acid concentration on conjugated linoleic acid production by Butyrivibrio fibrisolvens A38. Appl Environ Microbiol. 2000 Dec;66(12):5226-30.