General Information of Drug-Metabolizing Enzyme (DME) (ID: DEW0ADP)

DME Name Glycerol/diol dehydratase (dhaB)
Synonyms Glycerol dehydratase; Propanediol dehydratase pduC; DW068_00380; DW833_01860; DW972_05120; DWZ29_11920; ERS852450_01400; ERS852578_02468; dhaB
Gene Name dhaB
UniProt ID
A0A174DDZ6_9FIRM
INTEDE ID
DME1904
Gene ID
43269661
EC Number EC: 4.2.1.30
Lyases
Carbon-oxygen lyase
Hydro-lyase
EC: 4.2.1.30
Lineage Species: Anaerobutyricum hallii
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Anaerobutyricum
Species: Anaerobutyricum hallii
Tissue Distribution Primarily distributed in human gut.
Sequence
MRSKRFEYLDQRPVNQDGYAKEWPEVGFIAMNSPFDPTPSIKIVNGEVVEMDGKTKDEFD
MLDAFIARYAINLDFAEEAMATDSLEIARMLVDINVNRQECLKYTTAVTPAKLVEIVGNL
SVLEAMMGITKMRCRLKPANQCHVTNVKDNMVQIAADAAEAAVRGFAEMETTVGIVRYAP
FNAIAIMLGANVGRPGILTQCAVEEATELDLGMRGYTAYAETVSVYGTEDVFMDGDDTPW
SKAFLASCYASRGVKMRFTSGTGSEVQMGMAEGKSMLYLEARCLGVTRGAGVQGTQNGSV
SCIGVPAAVPGGIRAVACENLIAAMLDLENASSNDQSFTHSDLRRVARSIPQFIPGTDYI
CSGYSSTPNYDNMFAGSNWDADDYDDWCVIQRDLRVDAGLLPAREEEVVAARNKAAKAIQ
ALFRELGLPEITDEEVEAATYARGSQDMPDRDVVADLKAATDMLDRGVTGIDFVKALYKG
GFEDVAESIFNIQKAKVVGDYLHTASMLDDKFHVISAVNSPNCYEGPMTGYQISPELWEK
ISDIRTAVDPAKL
Function This enzyme has two forms. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 Discovery agent N.A. Investigative [1]

References

1 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.