Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEW0ADP)

DME Name	Glycerol/diol dehydratase (dhaB)
Synonyms	Glycerol dehydratase; Propanediol dehydratase pduC; DW068_00380; DW833_01860; DW972_05120; DWZ29_11920; ERS852450_01400; ERS852578_02468; dhaB
Gene Name	dhaB
UniProt ID	A0A174DDZ6_9FIRM
INTEDE ID	DME1904
Gene ID	43269661
EC Number	EC: 4.2.1.30 Lyases Carbon-oxygen lyase Hydro-lyase EC: 4.2.1.30
Lineage	Species: Anaerobutyricum hallii Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Anaerobutyricum Species: Anaerobutyricum hallii
Tissue Distribution	Primarily distributed in human gut.
Sequence	MRSKRFEYLDQRPVNQDGYAKEWPEVGFIAMNSPFDPTPSIKIVNGEVVEMDGKTKDEFD MLDAFIARYAINLDFAEEAMATDSLEIARMLVDINVNRQECLKYTTAVTPAKLVEIVGNL SVLEAMMGITKMRCRLKPANQCHVTNVKDNMVQIAADAAEAAVRGFAEMETTVGIVRYAP FNAIAIMLGANVGRPGILTQCAVEEATELDLGMRGYTAYAETVSVYGTEDVFMDGDDTPW SKAFLASCYASRGVKMRFTSGTGSEVQMGMAEGKSMLYLEARCLGVTRGAGVQGTQNGSV SCIGVPAAVPGGIRAVACENLIAAMLDLENASSNDQSFTHSDLRRVARSIPQFIPGTDYI CSGYSSTPNYDNMFAGSNWDADDYDDWCVIQRDLRVDAGLLPAREEEVVAARNKAAKAIQ ALFRELGLPEITDEEVEAATYARGSQDMPDRDVVADLKAATDMLDRGVTGIDFVKALYKG GFEDVAESIFNIQKAKVVGDYLHTASMLDDKFHVISAVNSPNCYEGPMTGYQISPELWEK ISDIRTAVDPAKL
Function	This enzyme has two forms. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------

References

1	Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.