Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEWD860)

DME Name	Linoleate 10-hydratase (10-LAH)
Synonyms	Linoleate hydratase; Oleate hydratase; Hydratase oleate; OA hydratase; Ohase; ohyA
Gene Name	10-LAH
UniProt ID	A0A1I9RYU9_LACPN
INTEDE ID	DME1338
EC Number	EC: 4.2.1.84 Lyases Carbon-oxygen lyase Hydro-lyase EC: 4.2.1.84
Lineage	Species: Lactobacillus plantarum Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus plantarum
Tissue Distribution	Primarily distributed in human gut.
Sequence	MVKSKAIMIGAGLSNMAAAVYLIQDGHWDGKDITFYGVDMHGANDGGATTDFTNEYWNKN HPMANTTGYVARGGRMLNYRTYVDLMDLLDRIPSVTEPGMTAAEDTRDFDVKHRTYDIAR LMQGGKGIINAGKLGFNNKDRTLLTKLIMMPDSEETKLDNVSIAEYFKDDPHMFQTNFWY MWETTFAFRTQSSAQELRRYMHQMIYEFTQIEHLVGVNRTRYNQFESMILPLIKYLQGQG VTFIDNKIVKDWQFKDTPMQDEITVTGLVIEDAQTGETEEVEVDEETAVIFTNGSITDSA TMGDYNTPAPENMDYGVSASLWKKATERFYNLGTPDKFFNDRNASEWVSFTLTTKNHLFL NEIVRITTQEPGNALNSFLSTTPITPLNQKDVNMSIVVHHQPHFTTQQPNETVLWGYFLY PRRQGEFVNKPYIKMTGKEMAQELIGQLSKVDPGPGNIKDKEKEILDSIVNNIPVYMPYA SALFNNRAKSDRPEVLPKHSTNLAFTGEFAEQPYQMIFTEQSAVRSGEIAAYHFAGVPMD NLVKTPRYDKDPKTLLKATKKMFD
Function	This enzyme catalyzes the conversion of linoleic acid to 10-hydroxy-12-octadecenoic acid.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LINOLEIC ACID	DMDGPY9	Discovery agent	N.A.	Investigative	[1]
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References

1	Characterization of linoleate 10-hydratase of Lactobacillus plantarum and novel antifungal metabolites. Front Microbiol. 2016 Oct 4;7:1561. eCollection 2016.