Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEWPAJD)

DME Name Aminoglycoside O-phosphotransferase (aphA6)
Synonyms Aminoglycoside 3'-phosphotransferase; Kanamycin kinase, type VI; Neomycin-kanamycin phosphotransferase type VI; APH(3')VI; aphA-6
Gene Name aphA-6
UniProt ID
KKA6_ACIBA
INTEDE ID
DME1068
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
20472049
EC Number EC: 2.7.1.95
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.95
Lineage Species: Acinetobacter baumannii
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Moraxellaceae
Genus: Acinetobacter
Species: Acinetobacter baumannii
Tissue Distribution Primarily distributed in human lung.
Sequence
MELPNIIQQFIGNSVLEPNKIGQSPSDVYSFNRNNETFFLKRSSTLYTETTYSVSREAKM
LSWLSEKLKVPELIMTFQDEQFEFMITKAINAKPISALFLTDQELLAIYKEALNLLNSIA
IIDCPFISNIDHRLKESKFFIDNQLLDDIDQDDFDTELWGDHKTYLSLWNELTETRVEER
LVFSHGDITDSNIFIDKFNEIYFLDLGRAGLADEFVDISFVERCLREDASEETAKIFLKH
LKNDRPDKRNYFLKLDELN
Function This enzyme acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
7 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amikacin DM5PDRB Bacteremia 1A73 Approved [1]
Framycetin DMF8DNE Acute liver failure DB91 Approved [1]
Gentamicin DMKINJO Bacteremia 1A73 Approved [1]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [1]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [1]
Streptomycin DME1LQN Bacterial infection 1A00-1C4Z Approved [1]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [1]
⏷ Show the Full List of 7 Approved Drug(s)

References

1 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.