Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEXCQTM)

DME Name	Arylamine N-acetyltransferase (NAT)
Synonyms	N-hydroxyarylamine O-acetyltransferase; nhoA; nat; NCTC10741_01829; SAMEA1712962_01653
Gene Name	nat
UniProt ID	A0A3P8LE58_TSUPA
INTEDE ID	DME1321
EC Number	EC: 2.3.1.5 Transferase Acyltransferase Acyltransferase EC: 2.3.1.5
Lineage	Species: Tsukamurella paurometabola Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Corynebacteriales Family: Tsukamurellaceae Genus: Tsukamurella Species: Tsukamurella paurometabola
Tissue Distribution	Primarily distributed in human lung.
Sequence	MNDDAAWGAPALDLPRYLHRIGLQAPPAPDLAGLSTLVRAHALTLPWENFDAVRGIPGEL TIDALQRRMIEGRRGYGCTGHVPLLAAALQRTGFRFGAASGRVLVDGGPSASTHALLIVE VDGAPHLAEVGFGAVPLAPLRLESGLEQDAGGWRYRLTAEAVGFGEEWRLDFLDPSSGQW RPQYRFALADRTWSDLRMTNFYVATSPHSPFRGRLMAVVNRPGERHVLTRDAVISTRPDG FRETVPYVAADRRAILAESFAIDLPEDEAAALAAVSGS
Function	This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1], [2]
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References

1	The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog. World J Microbiol Biotechnol. 2019 Oct 31;35(11):174.
2	Complete genome sequence of Tsukamurella paurometabola type strain (no. 33). Stand Genomic Sci. 2011 Jul 1;4(3):342-51.