Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEXNDR0)

• DME Name: Cytochrome P450 26C1 (CYP26C1)
• Synonyms: Cytochrome P450 family 26 subfamily C member 1; CYP26C1; FFDD4
• Gene Name: CYP26C1
• UniProt ID: CP26C_HUMAN
• INTEDE ID: DME0600
• Gene ID: 340665
• EC Number:
  EC: 1.14.11.1
  Oxidoreductase
  Oxygen paired donor oxidoreductase
  2-oxoglutarate donor oxidoreductase
  EC: 1.14.11.1
• Lineage:
  Species: Homo sapiens
  Kingdom: Metazoa
  Phylum: Chordata
  Class: Mammalia
  Order: Primates
  Family: Hominidae
  Genus: Homo
  Species: Homo sapiens
• Sequence:
  MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG
  ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS
  AHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVS
  VYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRAR
  DQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFT
  TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSL
  AALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV
  YRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTA
  RWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL
• Function: This enzyme plays a role in retinoic acid metabolism. And it acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA.
• KEGG Pathway:
  Metabolic pathways (hsa01100)
  Retinol metabolism (hsa00830)
• Reactome Pathway:
  RA biosynthesis pathway (R-HSA-5365859)
  Vitamins (R-HSA-211916)
  Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) (R-HSA-5579004)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1]

References

• [1] CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503.