Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEXTCU0)

DME Name Beta-galactosidase (bgaB)
Synonyms Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; 6-phospho-beta-galactosidase; Beta-D-phosphogalactoside galactohydrolase; Lebu_0590; P-beta-Gal; PBG; PGALase; lacG
Gene Name lacG
UniProt ID
LACG_LEPBD
INTEDE ID
DME1637
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number EC: 3.2.1.23
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.23
Lineage Species: Leptotrichia buccalis
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Leptotrichiaceae
Genus: Leptotrichia
Species: Leptotrichia buccalis
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MSKKLPEDFIFGGATAAYQAEGAIKIDGKGPVAWDKFLEENYWYTAEPASDFYHQYPVDL
KLCEEFGINGIRISIAWSRIFPNGYGEVNPKGVEFYHKLFAECKKRKVEPFVTLHHFDTP
EVLHSNGDFLNRENIEHFVNYAKFCFEEFSEVNYWTTFNEIGPIGDGQYLVGKFPPGIKY
DFEKLFQSHHNMVLAHAKAVNLFKKNGYHGEIGMVCALPTKYPYDPNNPKDVRAAELDDI
IHNKFILDATFKGEYSKNTMEGVNHILQVNGGKLDLREEDFEELKAAKDLNDFLGINYYM
SDWMAEYDGETEIIHNATGNKGSSKYQIKGVGQRKANESIPRTDWDWIIYPQGLYDQISR
VKKDYPNYKKIYITENGLGYKDVFEDNTVYDDARIDYIRQHLEVISDAIKDGANVKGYFL
WSLMDVFSWSNGYEKRYGLFYVDFETQKRYPKKSAYWYKKVSETKEV
Function This enzyme has 6-phospho-beta-galactosidase activity and galactosidase activity and takes part in lactose catabolic process.
KEGG Pathway
Galactose metabolism (lba00052 )
Metabolic pathways (lba01100 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
D-mannose DMT6X03 Discovery agent N.A. Investigative [1]

References

1 Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 2004 Mar;54(Pt 2):583-592.