Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEY2UXF)

• DME Name: Alpha-galactosidase (melA)
• Synonyms: Alpha-D-galactoside galactohydrolase; 1,6-alpha-D-galactoside galactohydrolase; Galactosidase alpha; Ag-I; Ag-II; Aga-F78; Aga-Y; AgaA; agaAJB13; AgaB; AgaI; LS1_00135; agaSK_1
• Gene Name: agaSK_1
• UniProt ID: A0A385XL22_9LACO
• INTEDE ID: DME2081
• EC Number:
  EC: 3.2.1.22
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.22
• Lineage:
  Species: Lactobacillus salivarius
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Lactobacillaceae
  Genus: Lactobacillus
  Species: Lactobacillus salivarius
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MPITYNEQSREFHLYNNKISYLIKILANEQLGQLYFGKRIPNRKNHDYLVENTYRPVTSY
  VFDDDYSFSLGNVKQEYPAYGTTDQRRPALDIKQPNGSRITDFKYVSHKIYAGKRKLTGL
  PATYVEDESEATTLEINLYDELIQVTLCLQYTIFENSAAIARSVKFSNDSDQKYQLKTAL
  SLNLDLPDANYEWLQFSGAWGRERHLHKTPLRPGIQAINSARGASSHMQNPFVILKRPFT
  TEEQGEALGVSFVYSGNFLAQAEVDEYSVTRLQIGIDPFQFSWCLKPNETFQTPEAILAY
  TSEGLNQLSQTFQKLYTTRLARGYWRDKERPILINNWEATYFDFTEEKLLSIAKKAKELG
  IELFVLDDGWFGERTKETAGLGDWYVNRNRLKNGISGLSRKIHDLGMMFGLWFEPEMVNK
  DSDLYRKHPDYIIETPKRHASHGRKQYVLDFSRKEVVDNIYEQLVKILDEGEIDYIKWDM
  NRNITECYSIAYPSEQQGEIMHRYILGVYDLYERLIERYPKILFESCASGGGRFDAGMLY
  YAPQAWTSDDSDAIERLKIQYGTSFGYPQSMMGAHVSASPNEQLGRNTPLKIRGDVAFFG
  AFGYELDLDKLSSTELASIKKQIELMKKYRSIFQYGTFYRLKSPFEGNIVSWMVVSEDKS
  QAIVGYYKILNDVNCEYRRLCLPGLDADTLYNVQEELGSYLGNFTGDELANIGLVTTDAS
  AGQNQETTDFYSKLFILERCGELSD
• Function: This enzyme hydrolyzes alpha-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[1]

References

• [1] Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8.