Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEYWTIQ)

DME Name	Aminoglycoside adenylyltransferase (aadA1a)
Synonyms	Streptomycin 3''-adenylyltransferase; Aminoglycosideadenylyl transferase; aadA; aadA1; aadA1a; ASQ14_26245; ASQ14_27545; FJR52_24735
Gene Name	aadA1a
UniProt ID	Q6YLD2_SALER
INTEDE ID	DME1632
Gene ID	39727563
EC Number	EC: 2.7.7.46 Transferase Kinase Nucleotidyltransferase EC: 2.7.7.46
Lineage	Species: Salmonella enterica Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Salmonella Species: Salmonella enterica
Tissue Distribution	Primarily distributed in human gut.
Sequence	MREAVIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDIDLLVTVTVRLDE TTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIPWRYPAKRELQFGEWQRNDILAG IFEPATIDIDLAILLTKAREHSVALVGPAAEELFDPVPEQDLFEALNETLTLWNSPPDWA GDERNVVLTLSRIWYSAVTGKIAPKDVAADWAMERLPAQYQPVILEARQAYLGQEEDRLA SRADQLEEFVHYVKGEITKVVGK
Function	This enzyme can use ATP, dATP, CTP, ITP and GTP as donors and kanamycin, tobramycin and sisomicin as acceptors. And it mediates bacterial resistance to the antibiotics streptomycin and spectomycin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spectinomycin	DM0MQ35	Acute gonococcal cervicitis		Approved	[1]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica. J Biol Chem. 2018 Jul 20;293(29):11481-11490.