General Information of Drug-Metabolizing Enzyme (DME) (ID: DEZKVM5)

DME Name Oligosaccharyltransferase (pglB)
Synonyms Oligosaccharyl transferase pglB; Oligo-saccharyl transferase; pglB; BCM31_07810
Gene Name pglB
UniProt ID
A0A2N3PLF6_9HELI
INTEDE ID
DME1502
EC Number EC: 2.4.99.19
Transferase
Glycosyltransferases
Glycosyltransferase
EC: 2.4.99.19
Lineage Species: Helicobacter winghamensis
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Helicobacter
Species: Helicobacter winghamensis
Tissue Distribution Primarily distributed in human gut.
Sequence
MLKSYSNFYILNKFSIHFLFITILCSIHFGFHYLDFKLLLDNPKNFISNTLILTSFDAYH
YAKGTREFLEILNAPSVQRIFHALSTLPFLSLLGGILAKCTSLSFSLGFSSVIFSATLAP
TLYALTYFNLNLLAQKRYFSKNSLAFIAFLASLIALFLPSFYQRVGAGYFDTDMLLLTLP
LCALLFLLRFIQTQRFLSLVLFVLFGFLAINWHNGIQNLFLLGFLLFLCVEILCALRLHV
ISKTHLMLASVFFVILTPSPFCLLTLIILLLAFRLYPKGIWFYFGIAIIYATTFGLFNPL
IAQINAYIFGSTQHASNLVFASVVNAILETSPTTLSVLVARSGGILIFTLGILGFGILLY
NAIFIFFKALISRQNPNKPLLYLSLFLLPFCFLGFFSLKLGVRFSFFLVPLIALGVALSL
LFFYAKCYRYLQLCIFTSSIILPLSLITITYSIPKPILSAQEIQAFKVLDSKLSTNDFIF
SWWDYGYALRYFTKAQVFLDGGRHSGAVNYPIAKILLSDSKELFYNFSMLLAQYLQNTDP
KVWNRIFSLMLKNADSKEFLDSLTQGYKNISLAHNAQVYWVLPMRVLPLLANINLFANLN
PENGKSLKNTSVFVFFDNTKLNFNTTINGTNTLLTQINLGQNSLLLSVDYLKSNIISLMI
FQKLPQNVCASGDSVRIYHLKDSKCAESLVQ
Function
This enzyme requires Mn2+ or Mg2+ and forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chains.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
4'-GALACTOSYLLACTOSE DMRF9NH Hyperlipidaemia 5C80 Investigative [1]

References

1 Characterization of N-linked protein glycosylation in Helicobacter pullorum. J Bacteriol. 2010 Oct;192(19):5228-36.