Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT0QE8EV)

DOT Name Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (OXCT2)
Synonyms EC 2.8.3.5; 3-oxoacid CoA-transferase 2A; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase; SCOT-t
Gene Name OXCT2
UniProt ID
SCOT2_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
2.8.3.5
Pfam ID
PF01144
Sequence
MAALRLLASVLGRGVPAGGSGLALSQGCARCFATSPRLRAKFYADPVEMVKDISDGATVM
IGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGVEDFGLGLLLAARQVRRIVCSYVGENT
LCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGAPIRYTPDGHL
ALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRAGNVVFRRSARNFNVPMCKAADV
TAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYEKRIERLTILKEEDGDAGKEEDART
RIIRRAALEFEDGMYANLGIGIPLLASNFISPSMTVHLHSENGILGLGPFPTEDEVDADL
INAGKQTVTVLPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMIPGKKVKGM
GGAMDLVSSQKTRVVVTMQHCTKDNTPKIMEKCTMPLTGKRCVDRIITEKAVFDVHRKKE
LTLRELWEGLTVDDIKKSTGCAFAVSPNLRPMQQVAP
Function
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Tissue Specificity Testis specific.
KEGG Pathway
Valine, leucine and isoleucine degradation (hsa00280 )
Butanoate metabolism (hsa00650 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Utilization of Ketone Bodies (R-HSA-77108 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
4 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (OXCT2). [1]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (OXCT2). [2]
Fenfluramine DM0762O Phase 3 Fenfluramine decreases the expression of Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (OXCT2). [3]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the expression of Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (OXCT2). [4]
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References

1 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
2 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
3 Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells. Pulm Circ. 2011 Jul-Sep;1(3):405-18. doi: 10.4103/2045-8932.87310.
4 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.