Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT0YA7JZ)

DOT Name Peptidyl-prolyl cis-trans isomerase A-like 4G (PPIAL4G)
Synonyms PPIase A-like 4G; EC 5.2.1.8; Peptidylprolyl cis-trans isomerase A-like 4
Gene Name PPIAL4G
UniProt ID
PAL4G_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
5.2.1.8
Pfam ID
PF00160
Sequence
MVNSVIFFDITVDGKPLGRISIKQFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGF
MCQGGDFTHPNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Epigallocatechin gallate DMCGWBJ Phase 3 Epigallocatechin gallate decreases the expression of Peptidyl-prolyl cis-trans isomerase A-like 4G (PPIAL4G). [1]
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 decreases the expression of Peptidyl-prolyl cis-trans isomerase A-like 4G (PPIAL4G). [1]
------------------------------------------------------------------------------------

References

1 Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.