Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT11JTKB)

DOT Name Nuclear pore complex-interacting protein family member A3 (NPIPA3)
Gene Name NPIPA3
UniProt ID
NPIA3_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF06409
Sequence
MFCCLGYEWLSGGCKTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCT
SYLCVSFLKTIFPSQNGHDGSTDVQQRARRSNRRRQEGIKIVLEDIFTLWRQVETKVRAK
ICKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHGEKERQVSEAEENGKLDMKEIHT
YMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAAEHRHSSGLPYWPYLTAETLK
NRMGHQPPPPTQQHSIIDNSLSLKTPPECLLTPLPPSALPSADDNLKTPAECLLYPLPPS
ADDNLKTPPECLLTPLPPSAPPSVDDNLKTPPKCVCSLPFHPQRMIISRN

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Nuclear pore complex-interacting protein family member A3 (NPIPA3). [1]
Leflunomide DMR8ONJ Phase 1 Trial Leflunomide decreases the expression of Nuclear pore complex-interacting protein family member A3 (NPIPA3). [2]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Nuclear pore complex-interacting protein family member A3 (NPIPA3). [3]
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References

1 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
2 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
3 Global gene expression analysis reveals novel transcription factors associated with long-term low-level exposure of EA.hy926 human endothelial cells to bisphenol A. Chem Biol Interact. 2023 Aug 25;381:110571. doi: 10.1016/j.cbi.2023.110571. Epub 2023 May 25.