Details of Drug Off-Target (DOT)
General Information of Drug Off-Target (DOT) (ID: OT19IXKJ)
DOT Name | Keratin-associated protein 10-1 (KRTAP10-1) | ||||
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Synonyms | High sulfur keratin-associated protein 10.1; Keratin-associated protein 10.1; Keratin-associated protein 18-1; Keratin-associated protein 18.1 | ||||
Gene Name | KRTAP10-1 | ||||
Related Disease | |||||
UniProt ID | |||||
3D Structure | |||||
Pfam ID | |||||
Sequence |
MAASTMSVCSSACSDSWQVDACPESCCEPHCCALSCCAPAPCLTLVCTPVSRVSSPCCQA
ACEPSPCQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCLPTCSKDSSS CCQQSSCQPTCCASSSSQQSCCVPVCCKPVCYVPTCSEDSSSCCQQSSCHPACCTSSPCQ QACCVPVRCKPVCCKPICCVPVCSGASTSCCQQSSCQPACCTTSCCRPSSSVSLLCRPVC RPACCMPVSSCCAPASSCQASCCRPASCVSLLCRPACSRPAC |
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Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
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Tissue Specificity | Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. | ||||
Reactome Pathway | |||||
Molecular Interaction Atlas (MIA) of This DOT
1 Disease(s) Related to This DOT
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Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||||
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2 Drug(s) Affected the Post-Translational Modifications of This DOT
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References