Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT1KN6H4)

DOT Name	Carbonic anhydrase 7 (CA7)
Synonyms	EC 4.2.1.1; Carbonate dehydratase VII; Carbonic anhydrase VII; CA-VII
Gene Name	CA7
UniProt ID	CAH7_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
PDB ID	3MDZ; 3ML5; 6G4T; 6H36; 6H37; 6H38; 6SDT; 6ZR9; 7NC4; 7P1A; 8Q3U
EC Number	4.2.1.1
Pfam ID	PF00194
Sequence	MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER IHMVNNFRPPQPLKGRVVKASFRA
Function	Reversible hydration of carbon dioxide.
KEGG Pathway	Nitrogen metabolism (hsa00910 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Reversible hydration of carbon dioxide (R-HSA-1475029 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

3 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Carbonic anhydrase 7 (CA7).	[1]
Arsenic	DMTL2Y1	Approved	Arsenic affects the methylation of Carbonic anhydrase 7 (CA7).	[3]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Carbonic anhydrase 7 (CA7).	[4]
------------------------------------------------------------------------------------

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Carbonic anhydrase 7 (CA7).	[2]
------------------------------------------------------------------------------------

References

1	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
2	Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
3	Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
4	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.