Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT1V0THS)

DOT Name Chemokine-like protein TAFA-1 (TAFA1)
Gene Name TAFA1
Related Disease
Brain disease ( )
UniProt ID
TAFA1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF12020
Sequence
MAMVSAMSWVLYLWISACAMLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEE
RSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCAT
GNKIKTTRIHPRT
Function Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation.
Tissue Specificity Brain-specific.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Brain disease DIS6ZC3X Strong Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Chemokine-like protein TAFA-1 (TAFA1). [2]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the methylation of Chemokine-like protein TAFA-1 (TAFA1). [3]
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References

1 FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation.FASEB J. 2018 May 25:fj201800020RRR. doi: 10.1096/fj.201800020RRR. Online ahead of print.
2 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
3 Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.