Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT1ZGH1K)

DOT Name Pleckstrin homology domain-containing family S member 1 (PLEKHS1)
Synonyms PH domain-containing family S member 1; Epididymis luminal protein 185; hEL185
Gene Name PLEKHS1
Related Disease
Advanced cancer ( )
Benign neoplasm ( )
Neoplasm ( )
UniProt ID
PKHS1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00169
Sequence
MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHH
HRGSIEIDQNSSVEVGISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDW
VSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKHL
MEQSSPGFRQTHLQDLSEATQDVKEENHYLTPRSVLLELDNIIASSDSGESIETDGPDQV
SGRIECHYEPMESSFFKETSHESVDSSKEEPQTLPETQDGDLHLQEQGSGIDWCLSPADV
EAQTTNDQKGNIPDESQVEKLNVFLSPPDVINYLALTEATGRICVSQWEGPPRLGCIFCH
GDHLLAVNDLKPQSLEEVSLFLTRSIQKEDSFRILSYQVAFGEGTELRDRAPGFRTSDRH
DVAKRACMESDWCRDSKTAPSTNLCLSFLFCKIMTNDGAGCWIIK

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Advanced cancer DISAT1Z9 Strong Biomarker [1]
Benign neoplasm DISDUXAD Strong Biomarker [1]
Neoplasm DISZKGEW Strong Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin increases the expression of Pleckstrin homology domain-containing family S member 1 (PLEKHS1). [2]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Pleckstrin homology domain-containing family S member 1 (PLEKHS1). [3]
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References

1 Genome-wide analysis of noncoding regulatory mutations in cancer.Nat Genet. 2014 Nov;46(11):1160-5. doi: 10.1038/ng.3101. Epub 2014 Sep 28.
2 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
3 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.