Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT2FLMUL)

DOT Name	Putative claudin-24 (CLDN24)
Synonyms	Claudin-21
Gene Name	CLDN24
UniProt ID	CLD24_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF00822
Sequence	MALIFRTAMQSVGLLLSLLGWILSIITTYLPHWKNLNLDLNEMENWTMGLWQTCVIQEEV GMQCKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLI LGGILSWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGG CLLNCAACSSHAPLALGHYAVAQMQTQCPYLEDGTADPQV
Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
KEGG Pathway	Cell adhesion molecules (hsa04514 ) Tight junction (hsa04530 ) Leukocyte transendothelial migration (hsa04670 ) Pathogenic Escherichia coli infection (hsa05130 ) Hepatitis C (hsa05160 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
PMID28460551-Compound-2	DM4DOUB	Patented	PMID28460551-Compound-2 increases the expression of Putative claudin-24 (CLDN24).	[1]
Milchsaure	DM462BT	Investigative	Milchsaure increases the expression of Putative claudin-24 (CLDN24).	[2]
------------------------------------------------------------------------------------

References

1	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
2	Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.