Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT3H2N9D)

DOT Name	Equatorin (EQTN)
Synonyms	Acrosome formation-associated factor
Gene Name	EQTN
Related Disease	Advanced cancer ( )
UniProt ID	EQTN_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF15339
Sequence	MNFILFIFIPGVFSLKSSTLKPTIEALPNVLPLNEDVNKQEEKNEDHTPNYAPANEKNGN YYKDIKQYVFTTQNPNGTESEISVRATTDLNFALKNDKTVNATTYEKSTIEEETTTSEPS HKNIQRSTPNVPAFWTMLAKAINGTAVVMDDKDQLFHPIPESDVNATQGENQPDLEDLKI KIMLGISLMTLLLFVVLLAFCSATLYKLRHLSYKSCESQYSVNPELATMSYFHPSEGVSD TSFSKSAESSTFLGTTSSDMRRSGTRTSESKIMTDIISIGSDNEMHENDESVTR
Function	Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.
Tissue Specificity	Isoform 1 is highly expressed in testis. Isoform 2 is expressed at low levels in skin and blood.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Advanced cancer	DISAT1Z9	Limited	Biomarker	[1]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Equatorin (EQTN).	[2]
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References

1	Isolation and characterisation of a novel human gene (C9orf11) on chromosome 9p21, a region frequently deleted in human cancer.Biochim Biophys Acta. 2000 Dec 15;1517(1):128-34. doi: 10.1016/s0167-4781(00)00272-4.
2	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.