Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT3ZLRH0)

• DOT Name: Serine/threonine-protein kinase 31 (STK31)
• Synonyms: EC 2.7.11.1; Serine/threonine-protein kinase NYD-SPK; Sugen kinase 396; SgK396
• Gene Name: STK31
• Related Disease:
  Advanced cancer
  Carcinoma of esophagus
  Colorectal carcinoma
  Esophageal cancer
  Neoplasm of esophagus
  Polyp of large intestine
  Neoplasm
  Pancreatic cancer
  Testicular cancer
• UniProt ID: STK31_HUMAN
• EC Number: 2.7.11.1
• Pfam ID: PF00069 ; PF00567
• Sequence:
  MWVQGHSSRASATESVSFSGIVQMDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMK
  IGCSLSEVCPQASSVLGNLDPNKIYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTE
  ILNRSDIVEIPLELQFSSVAKKYKLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIK
  ATSEDGTVIAQAEYGSVDIGEEVLKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPI
  PLWGHRSNQSTFSRPKGHLSEKMTLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKI
  KQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYI
  DTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSL
  AQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEA
  VYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEG
  SLISEDAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIA
  TVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPD
  GSQIEKIKEEITQLRNNVFQEIYHEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGG
  LLTMSLERDLLDAEPMKELSSKRPLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRA
  WREAEGDSGLLPLIFLFLCKSDPMAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQ
  GLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELK
  MGKPASPGSDLYAYGCLLLWLSVQNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSS
  MTAEQVLNAECFLMPKEQSVPNPEKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC
• Tissue Specificity: Testis specific.

Molecular Interaction Atlas (MIA) of This DOT

9 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Advanced cancer	DISAT1Z9	Strong	Biomarker	[1]
Carcinoma of esophagus	DISS6G4D	Strong	Altered Expression	[2]
Colorectal carcinoma	DIS5PYL0	Strong	Altered Expression	[3]
Esophageal cancer	DISGB2VN	Strong	Altered Expression	[2]
Neoplasm of esophagus	DISOLKAQ	Strong	Altered Expression	[2]
Polyp of large intestine	DISRE1MK	Strong	Altered Expression	[4]
Neoplasm	DISZKGEW	moderate	Biomarker	[4]
Pancreatic cancer	DISJC981	moderate	Altered Expression	[5]
Testicular cancer	DIS6HNYO	moderate	Biomarker	[6]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the expression of Serine/threonine-protein kinase 31 (STK31).	[7]

References

• [1] OncoScape: Exploring the cancer aberration landscape by genomic data fusion.Sci Rep. 2016 Jun 20;6:28103. doi: 10.1038/srep28103.
• [2] Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis.Cancer Res. 2008 Feb 15;68(4):1074-82. doi: 10.1158/0008-5472.CAN-07-0964.
• [3] Serine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells.J Cell Physiol. 2019 Mar;234(3):2649-2658. doi: 10.1002/jcp.27079. Epub 2018 Aug 24.
• [4] Serum FBLN1 and STK31 as biomarkers of colorectal cancer and their ability to noninvasively differentiate colorectal cancer from benign polyps.Clin Chim Acta. 2018 Aug;483:151-155. doi: 10.1016/j.cca.2018.04.038. Epub 2018 Apr 30.
• [5] The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer.Oncotarget. 2017 May 23;8(21):35154-35164. doi: 10.18632/oncotarget.16814.
• [6] STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer.Oncotarget. 2017 Apr 11;8(15):24354-24361. doi: 10.18632/oncotarget.15396.
• [7] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.