Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT425SIG)

DOT Name Leydig cell tumor 10 kDa protein homolog (C19ORF53)
Gene Name C19ORF53
Related Disease
Zika virus infection ( )
UniProt ID
L10K_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
8FLA; 8FLB; 8FLC; 8IDT; 8IDY; 8INE; 8INF
Pfam ID
PF09495
Sequence
MAQGQRKFQAHKPAKSKTAAAASEKNRGPRKGGRVIAPKKARVVQQQKLKKNLEVGIRKK
IEHDVVMKASSSLPKKLALLKAPAKKKGAAAATSSKTPS
Function May have a potential role in hypercalcemia of malignancy.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Zika virus infection DISQUCTY Strong Altered Expression [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Leydig cell tumor 10 kDa protein homolog (C19ORF53). [2]
chloropicrin DMSGBQA Investigative chloropicrin increases the expression of Leydig cell tumor 10 kDa protein homolog (C19ORF53). [3]
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References

1 Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions.Genomics Proteomics Bioinformatics. 2019 Jun;17(3):319-331. doi: 10.1016/j.gpb.2018.12.010. Epub 2019 Sep 5.
2 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
3 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.