Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT4F3AKI)

DOT Name T-cell surface glycoprotein CD1e, membrane-associated (CD1E)
Synonyms hCD1e; R2G1; CD antigen CD1e
Gene Name CD1E
Related Disease
Chronic inflammatory demyelinating polyneuropathy ( )
Malaria ( )
Multiple sclerosis ( )
Plasmodium falciparum malaria ( )
Vasculitis ( )
UniProt ID
CD1E_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
3S6C
Pfam ID
PF07654 ; PF16497
Sequence
MLLLFLLFEGLCCPGENTAAPQALQSYHLAAEEQLSFRMLQTSSFANHSWAHSEGSGWLG
DLQTHGWDTVLGTIRFLKPWSHGNFSKQELKNLQSLFQLYFHSFIQIVQASAGQFQLEYP
FEIQILAGCRMNAPQIFLNMAYQGSDFLSFQGISWEPSPGAGIRAQNICKVLNRYLDIKE
ILQSLLGHTCPRFLAGLMEAGESELKRKVKPEAWLSCGPSPGPGRLQLVCHVSGFYPKPV
WVMWMRGEQEQRGTQRGDVLPNADETWYLRATLDVAAGEAAGLSCRVKHSSLGGHDLIIH
WGGYSIFLILICLTVIVTLVILVVVDSRLKKQSSNKNILSPHTPSPVFLMGANTQDTKNS
RHQFCLAQVSWIKNRVLKKWKTRLNQLW
Function
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
Tissue Specificity Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
KEGG Pathway
Tight junction (hsa04530 )
Hematopoietic cell lineage (hsa04640 )
Amoebiasis (hsa05146 )

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Chronic inflammatory demyelinating polyneuropathy DISNGBLD Strong Genetic Variation [1]
Malaria DISQ9Y50 Strong Biomarker [2]
Multiple sclerosis DISB2WZI Strong Genetic Variation [3]
Plasmodium falciparum malaria DIS3Q9KF Strong Genetic Variation [2]
Vasculitis DISQRKDX Strong Genetic Variation [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of T-cell surface glycoprotein CD1e, membrane-associated (CD1E). [4]
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References

1 Polymorphisms of CD1 genes in chronic dysimmune neuropathies.J Neuroimmunol. 2007 May;186(1-2):161-3. doi: 10.1016/j.jneuroim.2007.03.001. Epub 2007 Apr 10.
2 Homozygosity for the CD1E*02 allele is associated with a resistance to Plasmodium falciparum malaria infection in Gabonese school children.Asian Pac J Trop Med. 2017 Feb;10(2):204-207. doi: 10.1016/j.apjtm.2017.01.017. Epub 2017 Jan 20.
3 CD1A and CD1E gene polymorphisms are associated with susceptibility to multiple sclerosis.Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):175-83. doi: 10.1177/039463201102400120.
4 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.