Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT53VYMN)

• DOT Name: Taste receptor type 1 member 2 (TAS1R2)
• Synonyms: G-protein coupled receptor 71; Sweet taste receptor T1R2
• Gene Name: TAS1R2
• Related Disease:
  Dental caries
  Parkinson disease
  Non-insulin dependent diabetes
• UniProt ID: TS1R2_HUMAN
• Pfam ID: PF00003 ; PF01094 ; PF07562
• Sequence:
  MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCK
  EYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDN
  LLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPAL
  LRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETL
  PTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIA
  SESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCN
  QECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQL
  LEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQD
  ISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPN
  NEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAG
  GPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFK
  MASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSC
  NPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFM
  SAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD
• Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
• KEGG Pathway:
  Taste transduction (hsa04742)
  Carbohydrate digestion and absorption (hsa04973)
• Reactome Pathway:
  Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)
  Sensory perception of sweet, bitter, and umami (glutamate) taste (R-HSA-9717207)
  G alpha (i) signalling events (R-HSA-418594)

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Dental caries	DISRBCMD	Strong	Genetic Variation	[1]
Parkinson disease	DISQVHKL	Strong	Genetic Variation	[2]
Non-insulin dependent diabetes	DISK1O5Z	Limited	Altered Expression	[3]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene affects the methylation of Taste receptor type 1 member 2 (TAS1R2).	[4]

References

• [1] A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health.Crit Rev Food Sci Nutr. 2018 Jan 22;58(2):194-207. doi: 10.1080/10408398.2016.1152229. Epub 2017 Jul 21.
• [2] Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain.J Neurochem. 2006 Jul;98(1):34-44. doi: 10.1111/j.1471-4159.2006.03801.x.
• [3] Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes.Gut. 2009 Mar;58(3):337-46. doi: 10.1136/gut.2008.148932. Epub 2008 Nov 27.
• [4] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.