Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT5LZ6GG)

DOT Name Testis-specific serine kinase substrate (TSKS)
Synonyms Testis-specific kinase substrate; STK22 substrate 1
Gene Name TSKS
Related Disease
Neoplasm ( )
Precancerous condition ( )
Seminoma ( )
UniProt ID
TSKS_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15358
Sequence
MASVVVKTIWQSKEIHEAGDTPTGVESCSQLVPEAPRRVTSRAKGIPKKKKAVSFHGVEP
QMSHQPMHWCLNLKRSSACTNVSLLNLAAMEPTDSTGTDSTVEDLSGQLTLAGPPASPTL
PWDPDDADITEILSGVNSGLVRAKDSITSLKEKTNRVNQHVQSLQSECSVLSENLERRRQ
EAEELEGYCIQLKENCWKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQE
AELQEPEEKQEPEEKQEPEEKQKPEAGLSWNSLGPAATSQGCPGPPGSPDKPSRPHGLVP
AGWGMGPRAGEGPYVSEQELQKLFTGIEELRREVSSLTARWHQEEGAVQEALRLLGGLGG
RVDGFLGQWERAQREQAQTARDLQELRGRADELCTMVERSAVSVASLRSELEGLGPLKPI
LEEFGRQFQNSRRGPDLSMNLDRSHQGNCARCASQGSQLSTESLQQLLDRALTSLVDEVK
QRGLTPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKP
EEKMATLDHLHLKMCSLHDHLSNLPLEGSTGTMGGGSSAGTPPKQGGSAPEQ
Function May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
Tissue Specificity Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Neoplasm DISZKGEW Strong Altered Expression [1]
Precancerous condition DISV06FL Strong Altered Expression [1]
Seminoma DIS3J8LJ Strong Altered Expression [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene affects the methylation of Testis-specific serine kinase substrate (TSKS). [2]
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References

1 Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors.Biochem Biophys Res Commun. 2001 Jul 13;285(2):400-8. doi: 10.1006/bbrc.2001.5165.
2 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.