Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT8CW0VN)

• DOT Name: Schlafen-like protein 1 (SLFNL1)
• Gene Name: SLFNL1
• UniProt ID: SLNL1_HUMAN
• Pfam ID: PF04326
• Sequence:
  MTPMKRSVQTQVSEPFMESWGEESLPELPAEQSLTEYSDLEEAPSAHTLYVGHLNPQFSV
  PVLACLLRDTLERLEMPVAREHIEVVRRPRKAYALVQVTVHRDTLASLPWRLQTALEEHL
  ILKELAARGKDLLLSEAQGPFSHREEKEEEEEDSGLSPGPSPGSGVPLPTWPTHTLPDRP
  QAQQLQSCQGRPSGVCSDSAIVHQQIVGKDQLFQGAFLGSETRNMEFKRGSGEYLSLAFK
  HHVRRYVCAFLNSEGGSLLVGVEDSGLVQGIRCSHRDEDRARLLVDSILQGFKPQIFPDA
  YTLTFIPVISTSETSVPLKVIRLTVHTPKAQSQPQLYQTDQGEVFLRRDGSIQGPLSASA
  IQEWCRQRWLVELGKLEEKMKALMMEKEQLQQQLQQHGPVSCTCCVL

Molecular Interaction Atlas (MIA) of This DOT

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Schlafen-like protein 1 (SLFNL1).	[1]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the methylation of Schlafen-like protein 1 (SLFNL1).	[2]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
QUERCITRIN	DM1DH96	Investigative	QUERCITRIN increases the expression of Schlafen-like protein 1 (SLFNL1).	[3]

References

• [1] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [2] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [3] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.