Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT8KS945)

DOT Name	GABA receptor subunit B1 (GABAB1)
Gene Name	GABAB1
UniProt ID	M9TEZ7_TETCI
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF00003 ; PF01094
Sequence	FFRTHPSATIHNPTRVKLFKEFKWQRIAIILEAEEVFVTTAKDLEYQCKKAGIEVLTRVT FLSDPSDAVKSLARQDARIIVGIFYGGEARKVMCEAYKQNLYGKQYVWFLLGWYEDNWYL PVKGLNCTKEEMLKVVQGHFTTEAIILNRDNKQTVAGITAQQWLDKYHQRLNQNLGTSVR PEGYQEAPLAYDAIWAVALALNATMHKLKKRGIAIESFNYENKLISQEIQNSLRDTFFLG VSGEVKFTDEGDRIALTQIEQMVNGNYNLLGYYDTQDDNLSWASAPQWLETGSPPKDRTV IVEQLKTVSLSFFVTLNAIAAIGIIWSIGLICFNFKFRKFRYIQMSQPLSNYIMLVGCIG CLSSVILFGLDSQKINARDFTKLCHSRAVLLSISFSLFFGAMFTKVWFAYRLSTQLEQSS KSKQKVENAQVVLMISLFCLIDVAILTSWFIKSPMIRITEKLEQEDVDPNDENIKIVRRL ERCDANLVWYCILFGYKGLLLLFGLFLAYETRSVKLKRLNDSRLVGMSIYNVVILCMITG PVSLVIVNHVDAHFAFIT

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Ethanol	DMDRQZU	Approved	GABA receptor subunit B1 (GABAB1) increases the Neurotoxicity ADR of Ethanol.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.