Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT8LTBA9)

DOT Name	Delta-aminolevulinic acid dehydratase (hemB)
Synonyms	EC 4.2.1.24
Gene Name	hemB
UniProt ID	Q5TJH2_9TELE
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	4.2.1.24
Pfam ID	PF00490
Sequence	MQTPVESVLHSGYFHPTLRCWQTCAADLRAENLIYPIFITDSEDAVEPIASLPGQARYGI NKLEGMLRPLVDNGLKCVLIFGVPANIEKDDRGSGADTAETPAVLGVKKIRSLFPDLLIA CDVCLCPYTSHGHCGILREDGTLDNDLSCLRLGEVALAYARAGCHIIAPSDMMDGRVRAI KQALMSNELGNKVSVLSYSAKFASCYYGPFRDAAQSKPAFGDRRCYQLPPGARGLALRAV ERDVREGADILMVKPGLPYLDIVREVKDKHPTHPLAVYNVSGEYAMLWHAAQAGAFDLRA AVMESMTSFRRAGADIIITYYVPQLLGWLKE
Function	Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Carbamazepine	DMZOLBI	Approved	Delta-aminolevulinic acid dehydratase (hemB) increases the Porphyria ADR of Carbamazepine.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.