Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT979K7Z)

DOT Name ADP-ribosylation factor-like protein 13A (ARL13A)
Gene Name ARL13A
Related Disease
Ciliopathy ( )
Meckel syndrome, type 1 ( )
Joubert syndrome ( )
UniProt ID
AR13A_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00025
Sequence
MFRLLSSCCSCLRTTEETRRNVTIPIIGLNNSGKTVLVEAFQKLLPSKTDHCMKSELTTL
LLDEYELSIYDLNGDLKGREAWPNYYAQAHGLVFVLDSSDIRRMQEVKIILTHLLSDKRV
AGKPILILANKQDKKKALMPCDIIDYLLLKKLVKENKCPCRVEPCSAIRNLERRNHQPIV
EGLRWLLAVIDTCQLPPTSSISISKNNTGSGERCSSHSFSTRTGMSKEKRQHLEQCSIEA
KPLKSILQKEGTRLWSKKNMSVTFALDEPMKEGECSRRMRAQNTTKLCYN

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Ciliopathy DIS10G4I Strong Genetic Variation [1]
Meckel syndrome, type 1 DIS4YWZU Strong Biomarker [1]
Joubert syndrome DIS7P5CO Limited Biomarker [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of ADP-ribosylation factor-like protein 13A (ARL13A). [3]
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References

1 Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.PLoS Genet. 2013;9(12):e1003977. doi: 10.1371/journal.pgen.1003977. Epub 2013 Dec 5.
2 Developmental expression of the zebrafish Arf-like small GTPase paralogs arl13a and arl13b.Gene Expr Patterns. 2018 Sep;29:82-87. doi: 10.1016/j.gep.2018.07.002. Epub 2018 Jul 17.
3 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.