Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTA6ZLP4)

DOT Name Alpha-lactalbumin (LALBA)
Synonyms Lactose synthase B protein; Lysozyme-like protein 7
Gene Name LALBA
UniProt ID
LALBA_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
1A4V; 1B9O; 1CB3; 1HML; 3B0I; 3B0O; 4L41
Pfam ID
PF00062
Sequence
MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAI
VENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFLDDDITDDIMCAKKILDIKGI
DYWLAHKALCTEKLEQWLCEKL
Function
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
Tissue Specificity Mammary gland specific. Secreted in milk.
KEGG Pathway
Galactose metabolism (hsa00052 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Lactose synthesis (R-HSA-5653890 )
BioCyc Pathway
MetaCyc:HS09571-MONOMER

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Amphotericin B DMTAJQE Approved Amphotericin B increases the expression of Alpha-lactalbumin (LALBA). [1]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Alpha-lactalbumin (LALBA). [2]
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References

1 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
2 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.