Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTABXTR0)

DOT Name Tektin-3 (TEKT3)
Gene Name TEKT3
Related Disease
Charcot marie tooth disease ( )
Spermatogenic failure 81 ( )
UniProt ID
TEKT3_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
7UNG
Pfam ID
PF03148
Sequence
MERVGCTLTTTYAHPRPTPTNFLPAISTMASSYRDRFPHSNLTHSLSLPWRPSTYYKVAS
NSPSVAPYCTRSQRVSENTMLPFVSNRTTFFTRYTPDDWYRSNLTNYQESNTSRHNSEKL
RVDTSRLIQDKYQQTRKTQADTTQNLGERVNDIGFWKSEIIHELDEMIGETNALTDVKKR
LERALMETEAPLQVARECLFHREKRMGIDLVHDEVEAQLLTEVDTILCCQERMKLHLDKA
IAQLAANRASQHELEKDLSDKQTAYRIDDKCHHLRNTSDGVGYFRGVERVDATVSVPESW
AKFTDDNILRSQSERAASAKLRDDIENLLVVTANEMWNQFNKVNLSFTNRIAETADAKNK
IQTHLAKTLQEIFQTEMTIESIKKAIKDKTAFLKVAQTRLDERTRRPNIELCRDMAQLRL
VNEVHEVDDTIQTLQQRLRDAEDTLQSLVHIKATLEYDLAVKANSLYIDQEKCMSMRKSY
PNTLRLVGFC
Function
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
Tissue Specificity Expressed in spermatozoa . Expressed in airway epithelial cells .

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Charcot marie tooth disease DIS3BT2L Strong Biomarker [1]
Spermatogenic failure 81 DISPQEVJ Limited Unknown [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Testosterone DM7HUNW Approved Testosterone decreases the expression of Tektin-3 (TEKT3). [3]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of Tektin-3 (TEKT3). [4]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the expression of Tektin-3 (TEKT3). [5]
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References

1 Determination of genomic copy number with quantitative microsphere hybridization.Hum Mutat. 2006 Apr;27(4):376-86. doi: 10.1002/humu.20312.
2 Tektin 3 is required for progressive sperm motility in mice. Mol Reprod Dev. 2009 May;76(5):453-9. doi: 10.1002/mrd.20957.
3 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
4 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
5 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.