Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTAN8ON8)

DOT Name	Putative protein PTGES3L (PTGES3L)
Synonyms	Prostaglandin E synthase 3-like
Gene Name	PTGES3L
UniProt ID	PTG3L_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAMARQHARTLWYDRPRYV FMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAKVNSKPVWLSVDFDNWRDW EGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLDDDSDSADDATSN

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Doxorubicin	DMVP5YE	Approved	Doxorubicin decreases the expression of Putative protein PTGES3L (PTGES3L).	[1]
Triclosan	DMZUR4N	Approved	Triclosan decreases the expression of Putative protein PTGES3L (PTGES3L).	[2]
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References

1	Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
2	Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.