Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTAUOF7Y)

• DOT Name: Guanylyl cyclase-activating protein 3 (GUCA1C)
• Synonyms: GCAP 3; Guanylate cyclase activator 1C
• Gene Name: GUCA1C
• UniProt ID: GUC1C_HUMAN
• PDB ID: 2GGZ
• Pfam ID: PF13202 ; PF13499
• Sequence:
  MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQV
  YNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAV
  QALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLR
  VICNGKQPDMETDSSKSPDKAGLGKVKMK
• Function: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
• Tissue Specificity: Retina.
• KEGG Pathway: Phototransduction (hsa04744)
• Reactome Pathway: Inactivation, recovery and regulation of the phototransduction cascade (R-HSA-2514859)

Molecular Interaction Atlas (MIA) of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Zoledronate	DMIXC7G	Approved	Zoledronate decreases the expression of Guanylyl cyclase-activating protein 3 (GUCA1C).	[1]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Guanylyl cyclase-activating protein 3 (GUCA1C).	[2]

References

• [1] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [2] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.