Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTB3ENN6)

• DOT Name: Maestro heat-like repeat-containing protein family member 6 (MROH6)
• Gene Name: MROH6
• Related Disease: Schizophrenia
• UniProt ID: MROH6_HUMAN
• Pfam ID: PF21047
• Sequence:
  MAGGVWGRSRAREAPVGALTLTALTEGIRARQGQPQGPPSAGPQPKSWEVKPEAEPQTQA
  LTAPSEAEPGRGATVPEAGSEPCSLNSALEPAPEGPHQVPQSSWEEGVLADLALYTAACL
  EEAGFAGTQATVLTLSSALEARGERLEDQVHALVRGLLAQVPSLAEGRPWRAALRVLSAL
  ALEHARDVVCALLPRSLPADRVAAELWRSLSRNQRVNGQVLVQLLWALKGASGPEPQALA
  ATRALGEMLAVSGCVGATRGFYPHLLLALVTQLHKLARSPCSPDMPKIWVLSHRGPPHSH
  ASCAVEALKALLTGDGGRMVVTCMEQAGGWRRLVGAHTHLEGVLLLASAMVAHADHHLRG
  LFADLLPRLRSADDPQRLTAMAFFTGLLQSRPTARLLREEVILERLLTWQGDPEPTVRWL
  GLLGLGHLALNRRKVRHVSTLLPALLGALGEGDARLVGAALGALRRLLLRPRAPVRLLSA
  ELGPRLPPLLDDTRDSIRASAVGLLGTLVRRGRGGLRLGLRGPLRKLVLQSLVPLLLRLH
  DPSRDAAESSEWTLARCDHAFCWGLLEELVTVAHYDSPEALSHLCCRLVQRYPGHVPNFL
  SQTQGYLRSPQDPLRRAAAVLIGFLVHHASPGCVNQDLLDSLFQDLGRLQSDPKPAVAAA
  AHVSAQQVAMLARARGCPRGPRLLRIAPRPARPPPVFADSPFQRRSVAGRWGCSGPRRA

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Schizophrenia	DISSRV2N	Strong	Genetic Variation	[1]

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Maestro heat-like repeat-containing protein family member 6 (MROH6).	[2]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of Maestro heat-like repeat-containing protein family member 6 (MROH6).	[5]

3 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Tretinoin	DM49DUI	Approved	Tretinoin decreases the expression of Maestro heat-like repeat-containing protein family member 6 (MROH6).	[3]
Urethane	DM7NSI0	Phase 4	Urethane increases the expression of Maestro heat-like repeat-containing protein family member 6 (MROH6).	[4]
PMID28460551-Compound-2	DM4DOUB	Patented	PMID28460551-Compound-2 increases the expression of Maestro heat-like repeat-containing protein family member 6 (MROH6).	[6]

References

• [1] Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.JAMA Psychiatry. 2019 Oct 1;76(10):1026-1034. doi: 10.1001/jamapsychiatry.2019.1335.
• [2] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [3] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [4] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [5] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [6] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.