Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTBVBINP)

DOT Name OTU domain-containing protein 6A (OTUD6A)
Synonyms EC 3.4.19.12; DUBA-2
Gene Name OTUD6A
Related Disease
Ovarian neoplasm ( )
UniProt ID
OTU6A_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
3.4.19.12
Pfam ID
PF02338
Sequence
MDDPKSEQQRILRRHQRERQELQAQIRSLKNSVPKTDKTKRKQLLQDVARMEAEMAQKHR
QELEKFQDDSSIESVVEDLAKMNLENRPPRSSKAHRKRERMESEERERQESIFQAEMSEH
LAGFKREEEEKLAAILGARGLEMKAIPADGHCMYRAIQDQLVFSVSVEMLRCRTASYMKK
HVDEFLPFFSNPETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQADS
PTLIIGEEYVKKPIILVYLRYAYSLGEHYNSVTPLEAGAAGGVLPRLL
Function Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Ovarian neoplasm DISEAFTY Strong Altered Expression [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of OTU domain-containing protein 6A (OTUD6A). [2]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene affects the methylation of OTU domain-containing protein 6A (OTUD6A). [3]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the methylation of OTU domain-containing protein 6A (OTUD6A). [4]
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References

1 Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase6A are differentially expressed in p53+/+ and p53-/- HCT116 cells.Int J Oncol. 2018 May;52(5):1705-1714. doi: 10.3892/ijo.2018.4302. Epub 2018 Mar 5.
2 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
3 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
4 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.