Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTDLYU1I)

DOT Name	Beta-defensin 127 (DEFB127)
Synonyms	Beta-defensin 27; DEFB-27; Defensin, beta 127
Gene Name	DEFB127
Related Disease	Acute myelogenous leukaemia ( )
UniProt ID	DB127_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF13841
Sequence	MGLFMIIAILLFQKPTVTEQLKKCWNNYVQGHCRKICRVNEVPEALCENGRYCCLNIKEL EACKKITKPPRPKPATLALTLQDYVTIIENFPSLKTQST
Function	Has antibacterial activity.
Reactome Pathway	Defensins (R-HSA-1461973 ) Beta defensins (R-HSA-1461957 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Acute myelogenous leukaemia	DISCSPTN	moderate	Genetic Variation	[1]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Beta-defensin 127 (DEFB127).	[2]
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References

1	Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.Oncotarget. 2017 Jan 31;8(5):7891-7899. doi: 10.18632/oncotarget.13631.
2	Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.