Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTEA9I59)

DOT Name Keratin, type I cuticular Ha5 (KRT35)
Synonyms Hair keratin, type I Ha5; Keratin-35; K35
Gene Name KRT35
Related Disease
Hepatitis B virus infection ( )
UniProt ID
KRT35_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00038
Sequence
MASKCLKAGFSSGSLKSPGGASGGSTRVSAMYSSSSCKLPSLSPVARSFSACSVGLGRSS
YRATSCLPALCLPAGGFATSYSGGGGWFGEGILTGNEKETMQSLNDRLAGYLEKVRQLEQ
ENASLESRIREWCEQQVPYMCPDYQSYFRTIEELQKKTLCSKAENARLVVEIDNAKLAAD
DFRTKYETEVSLRQLVESDINGLRRILDDLTLCKSDLEAQVESLKEELLCLKKNHEEEVN
SLRCQLGDRLNVEVDAAPPVDLNRVLEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVV
SSSEQLQSCQAEIIELRRTVNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQCMIT
NVEAQLAEIRADLERQNQEYQVLLDVRARLECEINTYRGLLESEDSKLPCNPCAPDYSPS
KSCLPCLPAASCGPSAARTNCSPRPICVPCPGGRF
Tissue Specificity Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.
KEGG Pathway
Estrogen sig.ling pathway (hsa04915 )
Staphylococcus aureus infection (hsa05150 )
Reactome Pathway
Formation of the cornified envelope (R-HSA-6809371 )
Keratinization (R-HSA-6805567 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Hepatitis B virus infection DISLQ2XY Strong Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Keratin, type I cuticular Ha5 (KRT35). [2]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Keratin, type I cuticular Ha5 (KRT35). [3]
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References

1 Transfection of a rat hepatoma cell line with a construct expressing human liver annexin V confers susceptibility to hepatitis B virus infection.Hepatology. 1999 Feb;29(2):576-84. doi: 10.1002/hep.510290238.
2 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
3 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.