Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTEMLDE6)

DOT Name Protein-lysine methyltransferase METTL21C (METTL21C)
Synonyms EC 2.1.1.-; Methyltransferase-like protein 21C
Gene Name METTL21C
Related Disease
Autism spectrum disorder ( )
Obesity ( )
Osteoporosis ( )
UniProt ID
MT21C_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
4MTL
EC Number
2.1.1.-
Pfam ID
PF10294
Sequence
MDVCLSSAQQPGRRGEGLSSPGGWLEAEKKGAPQKDSTGGVLEESNKIEPSLHSLQKFVP
TDYASYTQEHYRFAGKEIVIQESIESYGAVVWPGAMALCQYLEEHAEELNFQDAKILEIG
AGPGLVSIVASILGAQVTATDLPDVLGNLQYNLLKNTLQCTAHLPEVKELVWGEDLDKNF
PKSAFYYDYVLASDVVYHHYFLDKLLTTMVYLSQPGTVLLWANKFRFSTDYEFLDKFKQV
FDTTLLAEYPESSVKLFKGILKWD
Function Protein-lysine N-methyltransferase using S-adenosyl-L-methionine as methyl donor. Mono-di and trimethylates 'Lys-943' of AARS1.

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Autism spectrum disorder DISXK8NV Strong Biomarker [1]
Obesity DIS47Y1K Strong Genetic Variation [2]
Osteoporosis DISF2JE0 Strong Genetic Variation [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Protein-lysine methyltransferase METTL21C (METTL21C). [3]
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References

1 Genetic and epigenetic methylation defects and implication of the ERMN gene in autism spectrum disorders.Transl Psychiatry. 2016 Jul 12;6(7):e855. doi: 10.1038/tp.2016.120.
2 Association between SNPs and haplotypes in the METTL21C gene and peak bone mineral density and body composition in Chinese male nuclear families.J Bone Miner Metab. 2017 Jul;35(4):437-447. doi: 10.1007/s00774-016-0774-7. Epub 2016 Sep 14.
3 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.