Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTEUBPKL)

DOT Name	Membrane progestin receptor alpha (mpra)
Synonyms	mPR alpha; Membrane progesterone receptor
Gene Name	mpra
UniProt ID	MPRA_CYNNE
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF03006
Sequence	MATVVMEQIGRLFINAQQLRQIPQLLESAFPTLPCTVKVSDVPWVFRERHILTGYRQPDQ SWRYYFLTLFQRHNETLNVWTHLLAAFIILVKWQEISETVDFLRDPHAQPLFIVLLAAFT YLSFSALAHLLSAKSELSYYTFYFLDYVGVAVYQYGSALAHYYYAIEKEWHTKVQGLFLP AAAFLAWLTCFGCCYGKYASPELPKVANKLFQVVPSALAYCLDISPVVHRIYSCYQEGCS DPVVAYHFYHVVFFLIGAYFFCCPHPESLFPGKCDFIGQGHQLFHVFVVVCTLTQVEALR TDFTERRPFYERLHGDLAHDAVALFIFTACCSALTAFYVRQRVRASLHEKGE
Function	Steroid membrane receptor. Binds progesterone, progestin and 17-hydroxyprogesterone in vitro. Capable of mediating progestin-induced oocyte maturation.
Tissue Specificity	Strongly expressed in ovary and brain; lower expression in testis and pituitary. Not detected in heart, kidney, spleen, intestine, gill and muscle.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Medroxyprogesterone	DMBGWPH	Approved	Membrane progestin receptor alpha (mpra) increases the Breast cancer ADR of Medroxyprogesterone.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.