Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTEY9908)

DOT Name	MKRN2 opposite strand protein (MKRN2OS)
Synonyms	MKRN2 antisense RNA 1; MKRN2 antisense gene protein 1
Gene Name	MKRN2OS
UniProt ID	MKROS_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF16044
Sequence	MHCAEAGKALIKFNHCEKYIYSFSVPQCCPLCQQDLGSRKLEDAPVSIANPFTNGHQEKC SFLLRPTQGTFLREYDGRSDLHVGITNTNGVVYNYSAHGVQRDGEGWEESISIPLLQPNM YGMMEQWDKYLEDFSTSGAWLPHRYEDNHHNCYSYALTFINCVLMAEGRQQLDKGEFTEK YVVPRTRLASKFITLYRAIREHGFYVTDCPQQQAQPPEGGGLC

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Estradiol	DMUNTE3	Approved	Estradiol decreases the expression of MKRN2 opposite strand protein (MKRN2OS).	[1]
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References

1	17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.