Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTF3HI3N)

DOT Name Cancer-associated gene 1 protein (CAGE1)
Synonyms CAGE-1; Cancer/testis antigen 3; CT3
Gene Name CAGE1
Related Disease
Advanced cancer ( )
Neoplasm ( )
Squamous cell carcinoma ( )
Tarsal-carpal coalition syndrome ( )
Transitional cell carcinoma ( )
Adenocarcinoma ( )
Carcinoma ( )
UniProt ID
CAGE1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15066
Sequence
MNKDYQKFWSSPSDPVHFEVDTSHEKVESMSESDTMNVSNLSQGVMLSHSPICMETTGTT
CDLPQNEIKNFERENEYESTLCEDAYGTLDNLLNDNNIENYSTNALIQPVDTISISSLRQ
FETVCKFHWVEAFDDEMTEKPEFQSQVYNYAKDNNIKQDSFKEENPMETSVSANTDQLGN
EYFRQPPPRSPPLIHCSGEMLKFTEKSLAKSIAKESALNPSQPPSFLCKTAVPSKEIQNY
GEIPEMSVSYEKEVTAEGVERPEIVSTWSSAGISWRSEACRENCEMPDWEQSAESLQPVQ
EDMALNEVLQKLKHTNRKQEVRIQELQCSNLYLEKRVKELQMKITKQQVFIDVINKLKEN
VEELIEDKYKIILEKNDTKKTLQNLEEVLANTQKHLQESRNDKEMLQLQFKKIKANYVCL
QERYMTEMQQKNKSVSQYLEMDKTLSKKEEEVERLQQLKKELEKATASALDLLKREKEAQ
EQEFLSLQEEFQKLEKENLEERQKLKSRLEKLLTQVRNLQFMSENERTKNIKLQQQINEV
KNENAKLKQQVARSEEQNYVPKFETAQLKDQLEEVLKSDITKDTKTTHSNLLPDCSPCEE
RLNPADIKRASQLASKMHSLLALMVGLLTCQDIINSDAEHFKESEKVSDIMLQKLKSLHL
KKKTLDKEVIDCDSDEAKSIRDVPTLLGAKLDKYHSLNEELDFLVTSYEEIIECADQRLA
ISHSQIAHLEERNKHLEDLIRKPREKARKPRSKSLENHPKSMTMMPALFKENRNDLD
Tissue Specificity Testis-specific expression in normal tissues, but wide expression among cancer tissues and cell lines.

Molecular Interaction Atlas (MIA) of This DOT

7 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Advanced cancer DISAT1Z9 Strong Biomarker [1]
Neoplasm DISZKGEW Strong Biomarker [1]
Squamous cell carcinoma DISQVIFL Strong Posttranslational Modification [1]
Tarsal-carpal coalition syndrome DISY90L2 Strong Posttranslational Modification [1]
Transitional cell carcinoma DISWVVDR Strong Biomarker [1]
Adenocarcinoma DIS3IHTY moderate Biomarker [2]
Carcinoma DISH9F1N Limited Biomarker [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaldehyde DMJFKG4 Investigative Acetaldehyde decreases the expression of Cancer-associated gene 1 protein (CAGE1). [3]
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References

1 Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.Int J Mol Med. 2006 Oct;18(4):547-57.
2 High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder.Int J Mol Med. 2007 Oct;20(4):557-63.
3 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.