Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTFIHZ4O)

DOT Name Olfactory receptor 14J1 (OR14J1)
Synonyms Hs6M1-28; Olfactory receptor 5U1; Olfactory receptor OR6-25
Gene Name OR14J1
Related Disease
Common variable immunodeficiency ( )
Systemic lupus erythematosus ( )
Type-1 diabetes ( )
UniProt ID
O14J1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF13853
Sequence
MVNLTSMSGFLLMGFSDERKLQILHALVFLVTYLLALTGNLLIITIITVDRRLHSPMYYF
LKHLSLLDLCFISVTVPQSIANSLMGNGYISLVQCILQVFFFIALASSEVAILTVMSYDR
YAAICQPLHYETIMDPRACRHAVIAVWIAGGLSGLMHAAINFSIPLCGKRVIHQFFCDVP
QMLKLACSYEFINEIALAAFTTSAAFICLISIVLSYIRIFSTVLRIPSAEGRTKVFSTCL
PHLFVATFFLSAAGFEFLRLPSDSSSTVDLVFSVFYTVIPPTLNPVIYSLRNDSMKAALR
KMLSKEELPQRKMCLKAMFKL
Function Odorant receptor.
KEGG Pathway
Olfactory transduction (hsa04740 )
Reactome Pathway
Expression and translocation of olfactory receptors (R-HSA-9752946 )
Olfactory Signaling Pathway (R-HSA-381753 )

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Common variable immunodeficiency DISHE7JQ Limited Genetic Variation [1]
Systemic lupus erythematosus DISI1SZ7 Limited Genetic Variation [2]
Type-1 diabetes DIS7HLUB Limited Genetic Variation [3]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene affects the methylation of Olfactory receptor 14J1 (OR14J1). [4]
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References

1 Genome-wide association identifies diverse causes of common variable immunodeficiency.J Allergy Clin Immunol. 2011 Jun;127(6):1360-7.e6. doi: 10.1016/j.jaci.2011.02.039. Epub 2011 Apr 17.
2 GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.Genes Immun. 2014 Sep;15(6):347-54. doi: 10.1038/gene.2014.23. Epub 2014 May 29.
3 Haplotype specific alteration of diabetes MHC risk by olfactory receptor gene polymorphism.Autoimmun Rev. 2012 Dec;12(2):270-4. doi: 10.1016/j.autrev.2012.05.001. Epub 2012 May 8.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.