Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTFJU7Y0)

DOT Name	Dual specificity protein phosphatase CDC14C (CDC14C)
Synonyms	EC 3.1.3.16; EC 3.1.3.48; CDC14 cell division cycle 14 homolog C
Gene Name	CDC14C
UniProt ID	CC14C_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	3.1.3.16; 3.1.3.48
Pfam ID	PF00782 ; PF14671
Sequence	MRSSTLQDPRRRDPQDDVYVDITDRLRFAILYSRPKSASNVHYFSIDNELEYENFSEDFG PLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEA AYRILIFGDTPYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEK AENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDA KRFTDAGFDHHDLFFADGSTPTDAIVKRFLDICENAEGAIAVHCKAGLGRTGTLIACYIM KHYRMTAAETIAWVRICRPGLVIGPQQQFLVMKQTSLWLEGDYFRQRLKGQENGQHRAAF SKLLSGVDDISINGVENQDQQEPKPYSDDDEINGVTQGDRSRALKRRRQSKTNDILLPSP LAVLTFTLCSVVIWWIVCDYILPILLF
Function	Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Chlorothiazide	DMLHESP	Approved	Dual specificity protein phosphatase CDC14C (CDC14C) increases the Metabolic disorder ADR of Chlorothiazide.	[1]
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References

1	Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.