Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTGRM6L0)

DOT Name	C-type lectin domain family 19 member A (CLEC19A)
Gene Name	CLEC19A
Related Disease	Attention deficit hyperactivity disorder ( )
UniProt ID	CL19A_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF00059
Sequence	MQRWTLWAAAFLTLHSAQAFPQTDISISPALPELPLPSLCPLFWMEFKGHCYRFFPLNKT WAEADLYCSEFSVGRKSAKLASIHSWEENVFVYDLVNSCVPGIPADVWTGLHDHRQEGQF EWTDGSSYDYSYWDGSQPDDGVHADPEEEDCVQIWYRPTSALRSWNDNTCSRKFPFVCKI PSLTIH

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Attention deficit hyperactivity disorder	DISL8MX9	Strong	Biomarker	[1]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the expression of C-type lectin domain family 19 member A (CLEC19A).	[2]
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References

1	Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample.Mol Psychiatry. 2014 May;19(5):615-24. doi: 10.1038/mp.2013.72. Epub 2013 Jun 11.
2	Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.