Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTHCX3RI)

DOT Name Transmembrane protein 132E (TMEM132E)
Gene Name TMEM132E
Related Disease
Hearing loss, autosomal recessive 99 ( )
Late-onset Parkinson disease ( )
Panic disorder ( )
Breast cancer ( )
Breast carcinoma ( )
Hearing loss, autosomal recessive ( )
UniProt ID
T132E_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF16070 ; PF15706 ; PF15705
Sequence
MAPGMSGRGGAALLCLSALLAHASGRSHPASPSPPGPQASPVLPVSYRLSHTRLAFFLRE
ARPPSPAVANSSLQRSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERL
TVNWKVRAFIVRSHVPASQPVVQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAREVKSSC
RLSGGLATCLVRAELPLAWFGPPAPAAPPTARRKSPDGLEPEATGESQQAELYYTLHAPD
ASGGCGGSRRGAGPGVGARAESPTQHPLLRIGSISLFRPPPRRTLQEHRLDSNLMIRLPD
RPLKPGEVLSILLYLAPNSSSPSSPSVEHFTLRVKAKKGVTLLGTKSRSGQWHVTSELLT
GAKHSTATVDVAWAQSTPLPPREGQGPLEILQLDFEMENFTSQSVKRRIMWHIDYRGHGA
LPDLERAVTELTVIQRDVQAILPLAMDTEIINTAILTGRTVAIPVKVIAIEVNGLVLDIS
ALVECESDNEDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLNAPLEMTVWVPKLPLH
IELSDARLSQVKGWRVPILPDRRSVRESEDEDEEEEERRQSASRGCTLQYQHATLQVFTQ
FHTTSSEGTDQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHMVDSSTLAGLEPGTTPFKV
VSPLTEAVLGETLLTVTEEKVSITQLQAQVVASLALSLRPSPGSSHTILATTAAQQTLSF
LKQEALLSLWLSYSDGTTAPLSLYSPRDYGLLVSSLDEHVATVTQDRAFPLVVAEAEGSG
ELLRAELTIAESCQKTKRKSVLATTPVGLRVHFGRDEEDPTYDYPGPSQPGPGGGEDEAR
GAGPPGSALPAPEAPGPGTASPVVPPTEDFLPLPTGFLQVPRGLTDLEIGMYALLGVFCL
AILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNGQPLRVQGELSPPAGNPLET
VPAFCHGDHHSSGSSQTSVQSQVHGRGDGSSGGSARDQAEDPASSPTSKRKRVKFTTFTT
LPSEELAYDSVPAGEEDEEEEEDLGWGCPDVAGPTRPTAPPDLHNYMRRIKEIA
Function Required for normal inner ear hair cell function and hearing.

Molecular Interaction Atlas (MIA) of This DOT

6 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Hearing loss, autosomal recessive 99 DISR4PYA Strong Autosomal recessive [1]
Late-onset Parkinson disease DIS9IOUI Strong Biomarker [2]
Panic disorder DISD3VNY Strong Genetic Variation [2]
Breast cancer DIS7DPX1 moderate Genetic Variation [3]
Breast carcinoma DIS2UE88 moderate Genetic Variation [3]
Hearing loss, autosomal recessive DIS8G9R9 Supportive Autosomal recessive [4]
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⏷ Show the Full List of 6 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Transmembrane protein 132E (TMEM132E). [5]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Transmembrane protein 132E (TMEM132E). [6]
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References

1 Kinetics of ligand binding to ferrous heme groups of hemoglobin MSaskatoon. J Mol Biol. 1975 Feb 5;91(4):471-5. doi: 10.1016/0022-2836(75)90273-9.
2 Are TMEM genes potential candidate genes for panic disorder?.Psychiatr Genet. 2014 Feb;24(1):37-41. doi: 10.1097/YPG.0000000000000022.
3 Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.Endocr Relat Cancer. 2013 Nov 4;20(6):875-87. doi: 10.1530/ERC-13-0349. Print 2013 Dec.
4 Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing loss DFNB99. Hum Mutat. 2015 Jan;36(1):98-105. doi: 10.1002/humu.22712. Epub 2014 Nov 28.
5 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
6 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.