Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTHYR2VI)

• DOT Name: Tripartite motif-containing protein 43B (TRIM43B)
• Gene Name: TRIM43B
• UniProt ID: TR43B_HUMAN
• Pfam ID: PF00622 ; PF00643 ; PF15227
• Sequence:
  MDSDFSHAFQKELTCVICLNYLVDPVTICCGHSFCRPCLCLSWEEAQSPANCPACREPSP
  KMDFKTNILLKNLVTIARKASLWQFLSSEKQICGTHRQTKKMFCDMDKSLLCLLCSNSQE
  HGAHKHYPIEEAAEEDREKLLKQMRILWKKIQENQRNLYEERRTAFLLRGDVVLRAQMIR
  NEYRKLHPVLHKEEKQHLERLNKEYQEIFQQLQRSWVKMDQKSKHLKEMYQELMEMCHKP
  EVELLQDLGDIVARSESVLLHMPQPVNPELTAGPITGLVYRLNRFRVEISFHFEVTNHNI
  RLFEDVRSWMFRRGPLNSDRSDYFAAWGARVFSFGKHYWELDVDNSCDWALGVCNNSWIR
  KNSTMVNSEDIFLLLCLKVDNHFNLLTTSPVFPHYIEKPLGRVGVFLDFESGSVSFLNVT
  KSSLIWSYPAGSLTFPVRPFFYTGHR

Molecular Interaction Atlas (MIA) of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Estradiol	DMUNTE3	Approved	Estradiol decreases the expression of Tripartite motif-containing protein 43B (TRIM43B).	[1]
Genistein	DM0JETC	Phase 2/3	Genistein decreases the expression of Tripartite motif-containing protein 43B (TRIM43B).	[1]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Tripartite motif-containing protein 43B (TRIM43B).	[2]

References

• [1] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [2] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.